Download e-book for kindle: Targeted therapies in cancer : with 25 tables by Manfred Dietel

By Manfred Dietel

ISBN-10: 354046090X

ISBN-13: 9783540460909

From its creation, oncological chemotherapy has been laden via negative selectivity simply because antiproliferative medicinal drugs are frequently poisonous not just to tumor cells but additionally to special populations of the body’s non-neoplastic cells. sleek certain treatments engage with outlined molecules current on melanoma cells, including elevated selectivity to their poisonous results. This ebook offers an built-in severe view at the theories, mechanisms, difficulties and pitfalls of the particular remedy approach.

Show description

Read Online or Download Targeted therapies in cancer : with 25 tables PDF

Similar cancer books

Manfred Dietel's Targeted therapies in cancer : with 25 tables PDF

From its advent, oncological chemotherapy has been laden through terrible selectivity simply because antiproliferative medicines are usually poisonous not just to tumor cells but additionally to big populations of the body’s non-neoplastic cells. glossy specific remedies engage with outlined molecules current on melanoma cells, including elevated selectivity to their poisonous results.

Download e-book for kindle: Human Cancer Markers by William C. Raschke (auth.), Stewart Sell, Britta Wahren

The power to diagnose melanoma by way of basic dimension of a serum or tissue' 'marker" has been a objective of scientific technological know-how for a few years. there's considerable proof that tumor cells are diversified from common cells and seasoned­ duce components that may be detected by means of at present to be had immuno­ chemical or biochemical equipment.

Chemotherapy: Volume 7 Cancer Chemotherapy I by Emil Frei III (auth.), K. Hellmann, T. A. Connors (eds.) PDF

The foreign Society of Chemotherapy meets each years to check development in chemotherapy of infections and of malignant sickness. every one assembly will get higher to surround the extension of chemotherapy into new components. In a few situations, growth has been speedy, for instance in cephalosporins, pen­ icillins and mix chemotherapy of melanoma - in others sluggish, as within the box of parasitology.

Extra info for Targeted therapies in cancer : with 25 tables

Sample text

Carcinogenesis 20:1369–1373 Hosono S, Gross I, English MA, Hajra KM, Fearon ER, Licht JD (2000) E-cadherin is a WT1 target gene. J Biol Chem 275:10943–10953 Hsieh AC, Bo R, Manola J, Vazquez F, Bare O, Khvorova A, Scaringe S, Sellers WR (2004) A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res 32:893–901 21 Ichikawa Y, Nishida M, Suzuki H, Yoshida S, Tsunoda H, Kubo T, Uchida K, Miwa M (1994) Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.

2006). 19 Acknowledgements Our work was supported by Berliner Krebsgesellschaft, Dr. Mildred-Scheel-Stiftung, and Deutsche Forschungsgemeinschaft (SFB 618). References Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997) Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res 57:2029–2034 Abdollahi A, Bao R, Hamilton TC (1999) LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.

To monitor the multiple altera- Fig. 1 Complex mechanisms of drug resistance in malignant tumour cells 28 tions, highly parallel analyses, such as the DNA microarray technique, are required. This opportunity opens new dimensions to predict therapy resistance and sensitivity. A recent NIH-study (Scherf et al. 000 different agents, one at a time and independently. Among other results, the study linked bioinformatics and chemoinformatics by relating cellular drug response with genetic information derived from DNA microarrays.

Download PDF sample

Targeted therapies in cancer : with 25 tables by Manfred Dietel


by Donald
4.2

Rated 4.65 of 5 – based on 39 votes