Download e-book for kindle: Human Cancer Markers by William C. Raschke (auth.), Stewart Sell, Britta Wahren

By William C. Raschke (auth.), Stewart Sell, Britta Wahren (eds.)

ISBN-10: 1461258081

ISBN-13: 9781461258087

ISBN-10: 1461258103

ISBN-13: 9781461258100

The skill to diagnose melanoma by means of uncomplicated size of a serum or tissue' 'marker" has been a aim of scientific technological know-how for a few years. there's plentiful proof that tumor cells are diversified from common cells and seasoned­ duce ingredients that may be detected via presently on hand immuno­ chemical or biochemical equipment. those "cancer markers" might be se­ creted proteins, enzymes, hormones, fetal serum parts, monoclonal immunoglobulins, mobile floor parts, or cytoplasmic parts. the aim of this ebook is to offer the present prestige of our wisdom of such melanoma markers. the 1st tumor marker pointed out via laboratory capability used to be Bence­ Jones protein. In a chain of lectures dropped at the Royal university of Phy­ sicians in London in 1846, Dr. H. Bence Jones defined experiences on a urine pattern despatched to him with the next notice: "Dear Dr. Jones-The tube comprises urine of very excessive particular gravity. while boiled it turns into somewhat opaque . . . . and so forth. " Dr. Jones came across that heating of the urine after addition of nitric acid ended in formation of a heavy precipitate; acid advert­ dition could have been required to convey the urine to pH 4-6 at which Bence Jones proteins usually tend to precipitate whilst heated. This urinary pre­ cipitate was once linked to a bone disorder termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].

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Download e-book for kindle: Human Cancer Markers by William C. Raschke (auth.), Stewart Sell, Britta Wahren

The power to diagnose melanoma via uncomplicated dimension of a serum or tissue' 'marker" has been a target of clinical technology for a few years. there's considerable facts that tumor cells are varied from general cells and professional­ duce components that may be detected by way of at the moment on hand immuno­ chemical or biochemical tools.

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1974). In each of these cases an anti -idiotype serum that reacts with unique binding site determinants on the monoclonal immunoglobulin protein isolated from the patient's serum was prepared and used to locate cells in the hematopoietic tissues bearing the idiotypic determinants. Virtually all stages of B lymphocyte development bearing the idiotypic marker could be identified in these tissues, implying that an early stage of B lymphocyte differentiation was oncogenically transformed. However, in these particular cases of multiple myeloma, the disease presented as a malignant plasma cell, the end stage of B lymphocyte maturation, presumably since the tumor cells continued differentiation and accumulated at this dead end.

1980) Abramson et al. (1980) Brooks et a!. (1980) McMichael et al. (1979) Reinherz et al. ) Koprowski et al. (1979) Koprowski et al. (1978) Steplewski et al. (1979) Koprowski et al. (1978) Steplewski et al. (1979) Yeh ct al. (1979) Woodbury et al. (1980) References m A I 0 (f) » JJ 0 5: 5> ~ r r C"> CEA -crossreacting antigen (NGP) Colonic mucosa Normal lung ND 180,000(CEA) CEA Colorectal carcinomas Same as Group I, except binds to 4 of 8 CRCs Pure CEA 1116NS-15 VII-23 ND ND ND Same as Group I, except binds to 5 of 8 CRCs and I of 10 melanomas Same as Group I, except binds to 5 of 8 CRCs 1116NS-52b 1116NS-36 1116NS-52a ND ND 1116NS_3b}1116NS-19 ND ND ND ND ND ND Same as Group I, except binds to 6 of 8 CRCs Same as Group I, except binds to 7 of 8 CRCs and I of 10 melanomas Same as Group I, except binds to only 7 of 8 CRCs Accolla et a!.

Acad. Sci. 75, 2411. , J. 1. Fox, and R. Warnke (1979), Proc. Natl. Acad. 76, 6552. , E. Hurwitz, R. Maron, R. Amon, and M. Sela (1975), Cancer Res. 35, 1182. L. C. M. Phillips, G. C. Bodenham, and P. Alexander (1969), Brit. Med. 1. 3, 547. , G. Froese, I. G. Israels (1974),1. Natl. Cancer Inst. 52, 1665. W. (1964), Science 145, 709. M. L. K. F. Greaves (1979), Cancer Immunol. Immunother. 6, 227. M. D. Scharff (1976), Cell 8, 405. , P. Fink, T. H. J. J. Gefter (1979), 1. Immunol. 122,2491. McGaughey, C.

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Human Cancer Markers by William C. Raschke (auth.), Stewart Sell, Britta Wahren (eds.)


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