By Benjamin Caballero, Richard J. Wurtman (auth.), Richard J. Wurtman M.D., Eva Ritter-Walker (eds.)
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Extra info for Dietary Phenylalanine and Brain Function
That it is important to study chronic intake of aspartame and not only single loading experiments.
1983). Effect of aspartame loading upon plasma and erythrocyte free amino acid concentrations in one-year-old infants. J. Nutr. 113: 1591-1599. J. (1978). Personal communication. L. (1977). Phenylalanine metabolism and intellectual functioning among carriers of phenylketonuria and hyperphenylalaninemia. Lancet i: 767-771. H. (1976). Use of aspartame by apparently healthy children and adolescents. J. Toxicol. Environ. Health 2:401-405. , and Salmona, M. (1986). Aspartame, brain amino acids and neurochemical mediators.
1987b). 5. Peak plasma phenylalanine concentrations were significantly higher and occurred significantly earlier when APM was given in solution. Similarly, the 4-h area under the plasma phenylalanine curve (AUC) was significantly greater after APM ingestion in solution than after ingestion in capsules. These data do not rule out the use of capsules for administration of APM in clinical studies. They do, however, point out that certain variables must be controlled. For example, the plasma pharmacokinetic response must be determined at the dose to be studied prior to double-blind testing of the compound for putative side effects.
Dietary Phenylalanine and Brain Function by Benjamin Caballero, Richard J. Wurtman (auth.), Richard J. Wurtman M.D., Eva Ritter-Walker (eds.)