Get Deprenyl — Past and Future: Journal of Neural Transmission PDF

By Prof. Dr. med. H. Braak, E. Braak, D. Yilmazer (auth.), Prof. Dr. W. Kuhn, Dr. P. Kraus, Prof. Dr. H. Przuntek (eds.)

ISBN-10: 3211828915

ISBN-13: 9783211828915

ISBN-10: 3709174945

ISBN-13: 9783709174944

Expert clinicians and easy scientists with a unique curiosity in Parkinson's affliction assessment the present country of technological know-how and medical therapeutics of the sickness. accordingly those articles characterize an authorative evaluation of the present nation of data concerning preclinical path and symptomatology, subtypes with their influence at the pathology, genetic changes, novel mechanisms of neuronal cellphone loss of life, diagnostic instruments and previous and novel healing methods with appreciate to neuroprotection and neuroregeneration in Parkinson's ailment. specific emphasis has been put on a singular antiparkinsonian drug known as budipine with a number of modes of motion additionally influencing altered non dopaminergic structures in Parkinson's illness. it really is obvious, that many questions about the reason, path and remedy of Parkinson's disorder are nonetheless unanswered and hence the fitting approach to deal with a parkinsonian sufferer is still defined.

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Additional resources for Deprenyl — Past and Future: Journal of Neural Transmission Supplement 48

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1992) and therefore is unlikely to underlie the apparent slowing of the progression of PD. , 1990), which seems to argue against inhibition of dopamine reuptake or increased dopamine release due to decreased dopamine catabolism as the basis for neurodegenerative slowing. , 1994). Prolonged treatment with irreversible MAO-B inhibitors, like deprenyl, induces MAO-A inhibition, even at doses insufficient to acutely inhibit MAO-A (Waldmeier and Feiner, 1978). Hence MAO-A rather than MAO-B inhibition could cause increased dopamine levels with prolonged (- )-deprenyl treatment and might explain the apparent slowing found in clinical trials.

6-Hydroxydopamine toxicity The 6-hydroxydopamine induced nigro-striatal degeneration can also be prevented by pre-treatment with (- )-deprenyl (Knoll, 1987). The mechanism underlying the neural degeneration depends on the formation of 6hydroxy quinone from 6-hydroxydopamine, which step is followed by an uptake into the dopaminergic nerve endings. 6-hydroxyquinone initiates neural degeneration due to the generation of free radicals. It was suggested that the protective effect of ( - )-deprenyl can be due to the combination of at least three factors: inhibition of MAO-B activity, potentiation of the free radical scavenging systems, and inhibition of DA re-uptake process (Knoll, 1987).

Magyar et al. , 1988). Similar results were published by Knoll and Magyar (1972) in mouse cerebral cortical slices. Nevertheless, the uptake inhibition by the metabolites of ( - )-deprenyl (methylamphetamine and amphetamine) cannot be ruled out as a contribution to the protective effect (see later). Thus of the three suggested mechanisms of the protection against 6hydroxydopamin toxicity, the inhibition of re-uptake appears to be the most important process. , 1990). Since both (- )-deprenyl and MDL 72974/A produce a comparable degree of MAO-B inhibition it seems doubtful that MAO-B activity play any significant role in the neurotoxicity of the substance.

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Deprenyl — Past and Future: Journal of Neural Transmission Supplement 48 by Prof. Dr. med. H. Braak, E. Braak, D. Yilmazer (auth.), Prof. Dr. W. Kuhn, Dr. P. Kraus, Prof. Dr. H. Przuntek (eds.)


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