By Michael A. Conway (Author), Joseph F. Clark (Author)
Creatine and Creatine Phosphate: clinical and scientific views is an updated precis of either the medical and scientific points of creatine and creatine phosphate metabolism and therapy.It covers intimately the fundamental biochemistry, bioenergetics and biophysics of those brokers with specific emphasis on their position at the cardiovascular and muscle structures. glossy in vivo myocardial and skeletal muscle measurements are defined, and the significance of the molecules in cardiovascular drugs, game technology and cardiac surgical procedure are highlighted.This publication is designed for these attracted to the fundamental medical history to creatine and creatine phosphate, and likewise for physicians treating or learning center and vascular disorder. The booklet can also be important for activities scientists who desire to collect a finished wisdom of the molecule that is presently being promoted for functionality and workout programmes.
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Extra resources for Creatine and Creatine Phosphate: Scientific and Clinical Perspectives
Compared with striated muscle, smooth muscle employs different strategies for the provision of ATP to meet energy demands. , 1979; Paul, 1983; Campbell and Paul, 1992). Contraction in vascular smooth muscle is characterized by only a twoto three-fold increase in ATP utilization. Since the ATP breakdown can be matched by aerobic resynthesis there is no apparent decrease in ATP+PCr content (Paul, 1980). , 1995) observed that at a perfusion concentration of 50 mM,/3-GPA rapidly enters vascular smooth muscle and becomes phosphorylated by CK, leading to the accumulation of fl-GPA-E fl-GPA phosphorylation occurs with a concomitant decrease in [PCr], [ATP] and [lactate].
B. and Roberts, R. (1983). Purification and characterization of human mitochondrial creatine kinase. J. Biol. Chem. 258, 15 346-15 354. , Pines, O. and Inouye, M. (1986). The role of antisense RNA in gene regulation. Ann. Rev. Biochem. 55, 569-597. , Roman, D. W. (1989). Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. J. Biol. Chem. 264, 2890-2897. , and DeLuca, M. (1975). Developmental changes in creatine phosphokinase isoenzymes in neonatal mouse hearts.
Acta 1206, 97-104. , Perryman, B. and Roberts, R. (1994). Improved quantification with validation of multiple mRNA species by polymerase chain reaction: application to human myocardial creatine kinase M and B. Cardiovasc. Res. 28, 467-477. Meerson, EZ. P. (1982). Isozyme pattern and activity of myocardial creatine phosphokinase under heart adaptation to prolonged overload. Basic Res. Cardiol. 77, 358-459. K. H. (1988). Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M.
Creatine and Creatine Phosphate: Scientific and Clinical Perspectives by Michael A. Conway (Author), Joseph F. Clark (Author)