By R. M. Clayton, D. E. S. Truman (auth.), R. M. Clayton, D. E. S. Truman (eds.)
The moment Edinburgh overseas Workshop used to be held in September, 1984 and took as its subject the coordinated law of gene expression. The goal of this sequence of workshops is to advertise trade of principles and information among scientists and clinicians whose pursuits span molecular and mobilephone biology, improvement and differentiation, oncology, and genetic and developmental pathologies. it really is was hoping that such interdisciplinary discussions can give upward thrust to fruitful insights. The conferences are based to offer considerable time for dialogue after every one formal presentation and culminate in a consultation of basic dialogue that's mentioned on the finish of the amount of complaints. we're very thankful to the members, all of whom participated within the dialogue and whose contributions have been necessary to the luck of the assembly. Novel principles have been usually recommend and explored completely from diverse angles. We ordinarily count on to accomplish really speedy ebook of the complaints of the assembly and are thankful to authors who produced typescripts in their contributions expeditiously, yet, as may possibly occasionally be the case with multi-author works, a few members had trouble in assembly schedules for filing manuscripts or corrections of the textual content of the dialogue, and in a single case now we have been not able to submit any checklist of the contribution. Our committment to the e-book of the dialogue, permitting individuals to make corrections to the transcript of the consultation, comparable to insertion of references and explanation of oral contributions, has additionally imposed a few delay.
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Extra info for Coordinated Regulation of Gene Expression
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These observations suggest that a major determinant of the changes of apoptosis within the nucleus is the activation of endonuclease enzymes, apparently in the absence of substantial proteolytic activity. We therefore set about attempting to isolate the enzymes responsible. NUCLEAR ENDONUCLEASE ACTIVITY IN APOPTOSIS Rodent and human thymocytes contain an endonuclease, active at neutral pH, which is dependent on the coincident presence of calcium and magnesium, and which cleaves chromatin at dispersed internucleosomal sites (Cohen & Duke, 1984; Wyllie, Morris & Watt, 1986).
Coordinated Regulation of Gene Expression by R. M. Clayton, D. E. S. Truman (auth.), R. M. Clayton, D. E. S. Truman (eds.)