By Michael D. Privitera MD;Jennifer Cavitt MD;David M. Ficker MD;Jerzy P. Szaflarski MD PhD;Timothy E. Welty PharmD FCCP BCPS;Marcia J. Kaplan MD
Designed for speedy point-of-care reference, this guide bargains evidence-based directions on use of antiepileptic medications for seizures, psychiatric issues, soreness, and headache. Chapters conceal all medicinal drugs, together with the lately authorized drug pregabalin. for every drug, the authors checklist FDA-approved symptoms and summarize the proof for efficacy and tolerability from medical trials for epileptic, psychiatric, soreness, and headache symptoms. additionally integrated are options from specialist societies reminiscent of the yank Academy of Neurology, American Psychiatric organization, and organization for the examine of Headache. Tables within the ultimate bankruptcy summarize those thoughts and point out the authors' collection of drug in a variety of scientific situations.
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Extra resources for Clinician’s Guide to Antiepileptic Drug Use
1 mEq/L; n = 121), or placebo (n = 121) monotherapy for up to 18 months. c. Number of Patients. See Comparator d. Primary Outcome Variable. , depressive, manic, hypomanic, or mixed) e. Results. Time to intervention for any mood episode was statistically superior for both lamotrigine and lithium compared to placebo. Lamotrigine was statistically superior to placebo in prolonging the time to intervention for a depressive episode. Lithium was statistically superior to placebo in prolonging the time to intervention for a manic or hypomanic episode.
Retention in trial for 12 months Important Secondary Outcome Variables. Freedom from seizure at 12 months, time to first seizure, drug toxicity Lamotrigine 51 e. Results. Lamotrigine and gabapentin were superior to carbamazepine in 12-month retention. Fewer withdrawals were observed with lamotrigine compared to that with gabapentin or carbamazepine. No differences in seizurefree rates were observed. B. Epilepsy (Refractory)—Adjunctive Treatment 1. Study Type. RCT7 a. Main Entry Criteria. Adults with medicationresistant seizures b.
Main Entry Criteria. Children 4 to 12 years with newly diagnosed absence seizures b. Comparator. Monotherapy gabapentin 19 mg/kg/day versus placebo c. Number of Patients. 33 d. Primary Outcome Variable; Important Secondary Variables. Percentage change in seizure frequency from baseline e. Results. No significant difference was seen between the gabapentin group and placebo group in the absence of seizure frequency. F. Pain—Postherpetic Neuralgia 1. Study Type. RCT14 a. Main Entry Criteria. Patients ≥18 years with postherpetic neuralgia b.
Clinician’s Guide to Antiepileptic Drug Use by Michael D. Privitera MD;Jennifer Cavitt MD;David M. Ficker MD;Jerzy P. Szaflarski MD PhD;Timothy E. Welty PharmD FCCP BCPS;Marcia J. Kaplan MD