By M. deBroe, et al.
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In a review of 6 publications which analyzed risk factors for contrast-associated nephropathy in 1416 patients, renal insufficiency was the only uniformly consistent factor for all studies , however, in 3 of 5 studies in which it was tested, the amount of contrast was found to correlate in a positive way. Cigarroa et al.  have used a modified contrast media dosing scheme for patients at high risk for contrastassociated nephropathy and reported that virtually every case of post procedure contrast-associated nephropathy occurred when the recommended limits of the calculated dose of contrast were exceeded.
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Clinical Nephrotoxins by M. deBroe, et al.