By M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. Henningsen, J.-N. Petrovici (eds.)
AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) have been the 1st to submit a paper about the in vivo thrombus detection with 111- In-labelled platelets. past makes an attempt at scintigraphic thrombus localisation were disappointing as a result of unspecific binding of a few of the isotopes used, in addition to the terrible labelling potency or an inadequate low gamma-emitting estate. as a result of its actual features (2.8 days half-life, ninety four% gamma emission) 111 Indium became out to be the easiest isotope for platelet kinetic reviews in addition to for the dimension of platelet incorporation via Thrombi for use up formerly. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets with no changing the functionality or the existence span of the platelets. This virtue has enable to a rise within the scientific functions of 1211-In labelled platelets. this present day, radiolabelled platelets are used for thrombus detection in different assorted scientific components resembling cardiology, nephrology. angiology or neurology. although many scientists and medical institution medical professionals now generally use radiolabelled platelet as a diagnostic software, there's as but now not a standardized labelling approach. as well as this, there are neither standardized photo approaches for the several scientific functions nor an contract approximately specificity and sensitivity of the strategy. In 1983, a symposium on Radiolabelled mobile Blood components was once geared up by way of M.Thakur, M.R.Hardeman and M.D.
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Blood cells in nuclear medicine. Part 1. The Haque: Nijhoff. 17-28 Murphy S, Gardner TH. Platelet preservation. Effect of storage temperature in maintenance of platelet viability - deleterious effect of refrigerated storage. 1969:280: 1094-1098 Morrison TS, Baldini M. The favorable effect of ACD on the viability of fresh and stored human platelets. Kinetics, distribution and sites of destruction of 111-Indium labelled human platelets. Haematol,1980:44:269-280. Intra hepatic kinetics of Indium 111labelled platelets.
1986) ±. 2 ±. 8 '? 25 other· authors S4 values found by Heyns (1986), Branehog (1977) and Harker (1969) are within the same range as our results with III-Intropolonate. 005). The range was very wide in patients with an ITP, but none had lower than normal values. Liver and spleen uptake after one hour in normals correlates well with the values found in literature (Table 5). Also, the absolute uptake in spleen and liver does not differ from values published by other authors. However, in the course of our investigation Dewanjee (1986) and duP.
1982) Platelet accumulation on mature Dacron grafts in man. Br. J. Surg. 69: 538-540. N. (1982) Femoro-popliteal Bypass Grafts - an Isotope Technique allowing in vivo comparison of Thrombogenicity. Br. J. Surg. 69(7): 380-382. N. (1986) The effect of the cyclo-oxygenase inhibitor Indobufen on platelet accumulation in prosthetic vascular grafts. Br. J. Surg. 73: 563-565. M. (1986) Radiolabelled platelets in the evaluation of platelet inhibitory therapy following carotid endarterectomy. Nucl. Med.
Clinical Application of Radiolabelled Platelets by M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. Henningsen, J.-N. Petrovici (eds.)