New PDF release: Cardiac Energetics: Basic Mechanisms and Clinical

By Dr. B. Brenner, E. Eisenberg (auth.), R. Jacob, Hj. Just, Ch. Holubarsch (eds.)

ISBN-10: 3662112892

ISBN-13: 9783662112892

ISBN-10: 3662112914

ISBN-13: 9783662112915

Assessment of cardiac energetics on the point of ATP-synthesis, chemomechanical strength transformation and entire organ dynamics as a functionality of haemodynamic load, ventricular configuration and oxygen- and substrates offer is uncomplicated to realizing cardiac functionality less than physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and middle failure) stipulations. in addition, cardiac energetics can be an incredible attention within the selection and alertness of gear specifically in terms of vasodilators, inotropic brokers and in cardioprotective measures. merely through contemplating energetics on the subcellular, mobile, and whole-heart point we will be able to arrive at a greater knowing of cardiac functionality and eventually larger medical judgement and drug remedy. Quantification of myocardial energetics also will aid to figure out the optimum time for surgical interventions reminiscent of valvular alternative or aneurysm resection. the current quantity is the end result of a world symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will surely aid bridge the prevailing hole among simple study regarding remoted buildings and that related to the total organ, at the one hand, and render the implications derived from uncomplicated learn appropriate to scientific difficulties, at the different hand.

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J Bioi Chern 254:6528-6537 24. Meyer RA, Brown TR, Kushmerick MJ (1985) Phosphorus magnetic resonance of fast- and slow-twitch muscle. Am J Physiol 248 (Cell PhysioI17):C279-C287 30 M. J. Kushmerick: Energetic studies of muscles of different types 25. Meyer RA, Kushmerick MJ, Brown TR (1982) Application of 31p_NMR spectroscopy to the study of striated muscle metabolism. Am J Physiol242 (Cell Physiol11): C1-C11 26. Meyer RA, Sweeney HL, Kushmerick MJ (1984) A simple analysis of the "phosphocreatine shuttle".

Alger JR, Shulman RG (1984) NMR studies of enzymatic rates in vitro and in vivo by magnetization transfer. Q Rev Biophys 17:83-124 2. Balaban RS, Kantor HL, Katz LA, Briggs RW (1986) Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science 232:1121-1123 3. Butler TM, Siegman MJ, Mooers SU, Barsotti RJ (1983) Myosin light chain phosphorylation does not modulate cross-bridge cycling rate in mouse skeletal muscle. Science 220: 1167-1169 4. Chance B, Williams GR (1956) The respiratory chain in cells and tissues.

Iii) The low QlO of basal cardiac metabolism relfects the relative temperature insensitivity of diffusive processes (passive leakage of protons). The calculation, which is based on Mitchell's chemiosmotic hypothesis [42], involves the following assumptions 1: (1) Hydrogen ions continuously leak across the inner mitochondrial membrane into the matrix. Leakage is through an electrical gradient of 150 m V [31] through a membrane of resistance 2 Mohm . 8 x 10- 13 mol H+ /cm 2 /s. 351 [45]. Myocardial specific density is assumed to be 1 g/cm 3 .

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Cardiac Energetics: Basic Mechanisms and Clinical Implications by Dr. B. Brenner, E. Eisenberg (auth.), R. Jacob, Hj. Just, Ch. Holubarsch (eds.)

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