By Dr. B. Brenner, E. Eisenberg (auth.), R. Jacob, Hj. Just, Ch. Holubarsch (eds.)
Assessment of cardiac energetics on the point of ATP-synthesis, chemomechanical strength transformation and entire organ dynamics as a functionality of haemodynamic load, ventricular configuration and oxygen- and substrates offer is uncomplicated to realizing cardiac functionality less than physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and middle failure) stipulations. in addition, cardiac energetics can be an incredible attention within the selection and alertness of gear specifically in terms of vasodilators, inotropic brokers and in cardioprotective measures. merely through contemplating energetics on the subcellular, mobile, and whole-heart point we will be able to arrive at a greater knowing of cardiac functionality and eventually larger medical judgement and drug remedy. Quantification of myocardial energetics also will aid to figure out the optimum time for surgical interventions reminiscent of valvular alternative or aneurysm resection. the current quantity is the end result of a world symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will surely aid bridge the prevailing hole among simple study regarding remoted buildings and that related to the total organ, at the one hand, and render the implications derived from uncomplicated learn appropriate to scientific difficulties, at the different hand.
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Additional resources for Cardiac Energetics: Basic Mechanisms and Clinical Implications
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Iii) The low QlO of basal cardiac metabolism relfects the relative temperature insensitivity of diffusive processes (passive leakage of protons). The calculation, which is based on Mitchell's chemiosmotic hypothesis , involves the following assumptions 1: (1) Hydrogen ions continuously leak across the inner mitochondrial membrane into the matrix. Leakage is through an electrical gradient of 150 m V  through a membrane of resistance 2 Mohm . 8 x 10- 13 mol H+ /cm 2 /s. 351 . Myocardial specific density is assumed to be 1 g/cm 3 .
Cardiac Energetics: Basic Mechanisms and Clinical Implications by Dr. B. Brenner, E. Eisenberg (auth.), R. Jacob, Hj. Just, Ch. Holubarsch (eds.)