Download PDF by Eric C. Schirmer, Jose I. de las Heras: Cancer Biology and the Nuclear Envelope: Recent Advances May

By Eric C. Schirmer, Jose I. de las Heras

ISBN-10: 1489980318

ISBN-13: 9781489980311

ISBN-10: 1489980326

ISBN-13: 9781489980328

This quantity brings jointly many alternative researchers and views protecting the historic and present use of the nuclear envelope in melanoma analysis and grading, transparent and very likely proper features of the nuclear envelope in cellphone cycler rules and signaling, chromatin association and gene expression, genome balance, nucleocytoplasmic delivery, mobilephone mechanical balance and migration, in addition to unforeseen hyperlinks among the nuclear envelope and tumorigenesis.

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Extra info for Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes

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M313157200 93. Apel ED, Lewis RM, Grady RM, Sanes JR (2000) Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem 275(41):31986–31995. M004775200 94. Clements L, Manilal S, Love DR, Morris GE (2000) Direct interaction between emerin and lamin A. Biochem Biophys Res Commun 267(3):709–714. 2023 95. Broers JL, Machiels BM, Kuijpers HJ, Smedts F, van den Kieboom R, Raymond Y, Ramaekers FC (1997) A- and B-type lamins are differentially expressed in normal human tissues.

Both lamin A-positive and lamin A-negative cells expressed Ki67. Lung Epithelium and Lung Cancer In normal lung as well as lung cancers the expression of lamins has been investigated using different techniques, including Northern blotting, Western blotting, and immunocytochemistry [8, 43]. From these studies it became clear that both in normal and neoplastic lung tissue a dramatic reduction of A-type lamins can occur. In normal lung lamin A/C expression is only observed in a subset of cells, relating to the differentiation stage of individual cells.

Normal Epidermis and Skin Cancer Epidermis Comparing the expression of A-type lamins as reported by different groups, one can immediately observe that there is a discrepancy between findings of different research groups. Initial studies by Röber et al. [6] showed a gradual increase in A-type lamin expression in all cell layers of the epidermis of mice starting at the later stages of embryonic development and continuing to increase after birth. Expression of these proteins in all epidermal layers was confirmed in paraffin sections of human epidermis [7].

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Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes by Eric C. Schirmer, Jose I. de las Heras

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