John M. Chirgwin Ph.D., G. David Roodman M.D., Ph.D.'s Bone Metastases: A translational and Clinical Approach PDF

By John M. Chirgwin Ph.D., G. David Roodman M.D., Ph.D. (auth.), Vassilios Vassiliou, Edward Chow, Dimitrios Kardamakis (eds.)

ISBN-10: 9400775687

ISBN-13: 9789400775688

ISBN-10: 9400775695

ISBN-13: 9789400775695

The moment version of this e-book serves either as an introductory and reference ebook targeting the sphere of metastatic bone sickness. that includes contributions from specialists within the box, this quantity describes the molecular and mobile mechanisms eager about the formation of bone metastases, offers the more recent advances made within the realizing of the medical photo and signs of sufferers, analyses the position of bone markers in examine and scientific perform and offers with all points of imaging modalities utilized for the detection and review of bone metastases. in addition, using all on hand remedy equipment, resembling radiotherapy, surgical procedure and systemic remedies for the administration of sufferers with metastatic bone disorder is mentioned intimately. total this quantity provides a radical evaluate of all features of metastatic bone sickness and offers a entire and concise info source for researchers, oncologists, orthopaedic surgeons and clinicians facing sufferers with metastatic bone disease.

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Additional info for Bone Metastases: A translational and Clinical Approach

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It tends to becomes more progressive and more severe in intensity over time. Bone pain can be hard for patients to differentiate from ordinary low back pain or from arthritis. If the lesion is in weight-bearing bone, the pain may worsen on weight-bearing and these lesions may cause pain early in the course of the disease, whereas bones such as the ribs or sternum may remain asymptomatic until later in the disease, often until the development of pathological fractures. Typically this type of pain is well-localized to one or more specific bone areas.

Early detection of bone marrow metastases enables earlier therapy [50] that may result in alleviation of pain [51] and prevention of complications of metastatic bone disease [52, 53]. Both magnetic resonance imaging (MRI) and bone marrow scintigraphy have proved to be effective in detecting bone marrow involvement, MRI being superior in terms of sensitivity and specificity [54]. Spinal cord compression is a medical emergency that calls for an urgent evaluation and treatment [7], since neurological recovery is probable only in the case that compression is relieved within 24–48 h from the time of diagnosis [55].

Bone metastases may also be associated with neuropathic pain mechanisms resulting from pressure on neural structures and/or maladaptive plasticity of the nervous system [17]. g. platinum compounds (cisplatin, carboplatin, oxaliplatin), taxanes (docetaxel, paclitaxel), vincristine, thalidomide and bortezomib) that may result in neuropathy. A recent prospective cross-sectional study of patients with symptomatic bone metastases showed that 17 % of patients had bone pain with distinguishable neuropathic pain features and these patients reported greater pain intensity [18].

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Bone Metastases: A translational and Clinical Approach by John M. Chirgwin Ph.D., G. David Roodman M.D., Ph.D. (auth.), Vassilios Vassiliou, Edward Chow, Dimitrios Kardamakis (eds.)


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