By A. Michael Parfitt (auth.), Sabrina C. Agarwal, Sam D. Stout (eds.)
With the turning out to be prevalence of fragility fractures in Europe and North the USA during the last 3 a long time, bone loss and osteoporosis became lively parts of analysis in skeletal biology. Bone loss is linked to getting older in either sexes and is speeded up in ladies with the onset of menopause. in spite of the fact that, bone loss is said to a collection of advanced and infrequently synergistically comparable components together with genetics, pathology, meals, mechani cal utilization, and way of life. it isn't spectacular that its occurrence and severity differ between populations. there was expanding curiosity to enquire bone loss and osteoporosis from an anthropological viewpoint that makes use of a biocultural method. Biocultural methods realize the inter-relationship among organic, cultural, and environmental variables. Anthropological reviews additionally spotlight the price of evolutionary and inhabitants ways to the examine of bone loss. those ways are really suited for elucidate the multifactorial etiology of bone loss. the belief for this quantity got here out of a symposium equipped by means of the editors on the seventieth annual assembly of the yank organization of actual Anthropologists in Kansas urban, Missouri. some of the symposium members, in addition to a number of extra prime scientists fascinated about bone and osteoporosis learn, are introduced jointly during this quantity. every one bankruptcy specializes in a special element of bone loss and fragility with a clean and stimulating perspective.
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Extra info for Bone Loss and Osteoporosis: An Anthropological Perspective
This focal imbalance can result either because 12 A. Michael Parfitt 1. Ce. -~ IJOSTEOID ~~. J 8. QUIESCENCE ~ 5. 5. Diagrammatic representation of the remodeling cycle in cancellous bone. Successive stages of quiescence, activation, resorption. reversal. formation. and back to quiescence at a single cross-sectional location generated by the movement of the BMU perpendicular to the plane of section are depicted. the so-called down and up model. Ce. Oc. = preosteoclast; Oc. Lc. Ln. = cement line; Ob.
Bone, 14, 435-441. M. (1994). Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. J. Cell. , 55, 273~286. M. (1 996a). Hormonal influences on bone remodeling and bone loss-application to the management of primary hyperparathyroidism. Ann. Intern. , 125, 413-41 S. M. (I 996b). Skeletal heterogeneity and the purposes of bone remodeling: Implications for the understanding of osteoporosis. In R Marcus, D. Feldman, and J. Kelsey (eds), Osteoporosis.
The so-called down and up model. Ce. Oc. = preosteoclast; Oc. Lc. Ln. = cement line; Ob. U. = bone structural unit (hemiosteon). Refilling is assumed to be complete, and bone marrow lying above the lining cells is omitted for clarity. Reproduced from Parfitt (1993b) with permission of the publisher. 6. Possible mechanisms of focal remodeling imbalance. (a) Normal depth resorption cavity on the left, completely refilled with new bone on the right. (b) Resorption cavity of excessive depth that is incompletely retilled by a normal amount of new bone.
Bone Loss and Osteoporosis: An Anthropological Perspective by A. Michael Parfitt (auth.), Sabrina C. Agarwal, Sam D. Stout (eds.)