By Stuart J Schnitt
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Extra resources for Biopsy Interpretation of the Breast
1998;152(6):1591-1598. 44. Larson PS, de las Morenas A, Bennett SR, Cupples LA, Rosenberg CL. Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas. Am J Pathol. 2002;161(1):283-290. 45. Graham K, Ge X, de Las Morenas A, Tripathi A, Rosenberg CL. Gene expression profiles of estrogen receptor-positive and estrogen receptor-negative breast cancers are detectable in histologically normal breast epithelium.
Shaaban AM, O’Neill PA, Davies MP, et al. Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia. Am J Surg Pathol. 2003;27(12):1502-1512. 36. Younes M, Honma N. Estrogen receptor beta. Arch Pathol Lab Med. 2011;135(1): 63-66. 37. Toker C. Clear cells of the nipple epidermis. Cancer. 1970;25(3):601-610. 38. Kohler S, Rouse RV, Smoller BR. The differential diagnosis of pagetoid cells in the epidermis. Mod Pathol. 1998;11(1):79-92. 39. Schnitt SJ, Goldwyn RM, Slavin SA.
Some of the cells have a hobnail appearance. Myoepithelial cells are inconspicuous. 20 Postmenopausal breast tissue. A: This sample consists primarily of fibrotic stroma with a few atrophic acini. B: In this specimen, a few residual, atrophic lobular acini are evident in a fatty stroma. 22 –––––– BIOPSY INTERPRETATION OF THE BREAST References 1. Osborne MP. Breast anatomy and development. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Diseases of the Breast. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2010:3-11.
Biopsy Interpretation of the Breast by Stuart J Schnitt