By Stojan Djokić
This quantity of recent facets of Electrochemistry stories the most recent advancements in electrochemical technological know-how and expertise regarding biomedical and pharmaceutical applications.
In specific, this booklet discusses electrochemical purposes to scientific units, implants, antimicrobially energetic fabrics, and drug supply systems.
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Additional info for Biomedical and Pharmaceutical Applications of Electrochemistry
5 μg/kg of body weight/day. Toxicity of silver is dose dependent. 5 μg/kg of body weight/day . Median lethal dose LD50 is the drug dose at which 50 % of the treated mice survive. , low levels are not cytotoxic . Wang et al. , sublethal doses) of silver have not been sufficiently considered . Ag NPs and ions can be involved in both lethal and sublethal doses. The direct indication of lethal cytotoxicity of nanosilver is cell death through increased ROS generation, oxidative stress, and enhanced permeability of mitochondrial membrane leading to overt toxic effects.
These modifications commonly comprise phosphorylation, addition of d-amino acids, methylation, amidation, glycosylation, etc. . 3 E xamples of Coatings Containing Antimicrobial Peptides on Titanium Several recent examples will be given on AMPs attached to titanium substrate by different methods. 9 μg/cm2 . The polymer brush was primary amine functionalized copolymer containing N,N-dimethylacrylamide and amino propyl methacrylamide hydrochloride prepared by radical polymerization. This layer was then immobilized using AMPs containing different sequences of amino acids (Tet-20, Tet-213, Tet-21, Tet-26, HH2, 1010cys, and MXXX226).
9 μg/cm2 . The polymer brush was primary amine functionalized copolymer containing N,N-dimethylacrylamide and amino propyl methacrylamide hydrochloride prepared by radical polymerization. This layer was then immobilized using AMPs containing different sequences of amino acids (Tet-20, Tet-213, Tet-21, Tet-26, HH2, 1010cys, and MXXX226). All investigated AMPs showed excellent antimicrobial activity toward P. 035 mm 2 [D1] 1500 1000 500 0 ium an Tit 20 sh 26 -213 10 ett etBru -10 Ti- ush-T sh-T h-Te rush s B Br Bru -Bru TiTiTiTi Fig.
Biomedical and Pharmaceutical Applications of Electrochemistry by Stojan Djokić