Download e-book for kindle: Aromatase inhibitors by B J A Furr

By B J A Furr

ISBN-10: 3764371994

ISBN-13: 9783764371999

ISBN-10: 3764374187

ISBN-13: 9783764374181

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These changes persist for several months after post-lactational involution and occur even without circulating ovarian oestrogens in ovariectomized mice, indicating that more than one event is required for tumour formation. These changes can be abrogated by aromatase inhibitors. Thus, early oestrogen exposure of mammary epithelial cells leads to preneoplastic changes, increases susceptibility to environmental carcinogens, and may result in acceleration and/or an increase in the incidence of breast cancer.

These model systems are valuable for studying the function of aromatase and the individual ERs in vivo. Int-5/aromatase model A model that has been valuable for investigating the role of oestrogen in breast cancer is the int-5/aromatase transgenic mouse developed by Tekmal and colleagues [40]. Aromatase overexpression contributes to increased oestrogenic activity in the mouse mammary gland, resulting in hyperplastic, dysplastic, and several premalignant changes. These changes persist for several months after post-lactational involution and occur even without circulating ovarian oestrogens in ovariectomized mice, indicating that more than one event is required for tumour formation.

Aromatase-knockout model Knowledge concerning the effects of oestrogens on different target tissues has been provided using disruption of the aromatase and ER gene (knockout models). Several models have been developed that include the aromatase-knockout mouse (ArKO) [38], the ERKO mouse (disrupted ER-α), the βERKO mouse (disrupted ER-β), as well as the α/βERKO-mouse (disrupted ER-α and ER-β) [39]. These model systems are valuable for studying the function of aromatase and the individual ERs in vivo.

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Aromatase inhibitors by B J A Furr


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