Download PDF by F. S. Philips (auth.), Franco M. Muggia, Charles W. Young,: Anthracycline Antibiotics in Cancer Therapy: Proceedings of

By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)

ISBN-10: 9400976305

ISBN-13: 9789400976306

ISBN-10: 9400976321

ISBN-13: 9789400976320

F. M. MUGGIA while confronted with the inadequacies of present melanoma remedy, we wish to examine what the long run may well carry. as a rule, we take without any consideration the earlier, who prefer examine into absolutely new components. even if, the chronic improvement of fertile soil may possibly yield stunning rewards if you happen to decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even though the anthracycline antibiotics symbolize a lot of the current and way forward for melanoma remedy, their real use c stretches again slightly 20 years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor homes of daunomycin and adriamycin. * The medical software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new desire for sufferers with sar­ comas and quite a few different tumors that have been deemed - sistant to chemotherapy. those successes have been tempered with the belief that the antitumor impression of anthracyclines can be accomplished every now and then basically on the very excessive rate of risking cardiac decompensation and, virtually constantly, with the incidence of alopecia and different acute toxicities. This list of prior achievements and difficulties has slowly given strategy to a gift more and more illuminated through our skill to change the distressing toxicities of those brokers. specific scientific reviews supplemented by means of creative laboratory types have steadily elucidated mechanisms and probability components im­ plicated within the cardiomyopathy.

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Additional resources for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981

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22. Giuliani F, Casazza AM, Di Marco A, Savi G. 1981. Cancer Treat. , ~, 267. 23. Arcamone F, Penco S, Vigevani A, Redaelli S, Franchi G, Di Marco A, Casazza AM, Dasdia T, Formelli F, Necco A, Soranzo C. 1975. J Med. , ~, 703. 24. Casazza AM, Di Marco A, Bertazzoli C, Formelli F, Giuliani F, Pratesi G. 1978. Current Chemotherapy. Am. Soc. Microbiology, Washington, 1257. 25. Giuliani F, Bellini 0, Casazza AM, Formelli F, Savi G, Di Marco A. 1978. Europ. J. Cancer, 14, 555. 26. Johnson RK, Chitnis MP, Embrey WM, Gregory EB.

Mg/kg) Rats with mammary tumors o 5/18 21/30 5/16 22/29 5 + o + 5 a Experimental conditions and treatment with cysteamine-HCl as in reference no. 15. 32 Table 2. of transformed foci per no. of dishes treated 0/12 8/12 13/11 20/12 0/12 7/11 13/12 17/18 a Experimental conditions and treatment with cysteamine-HCl as in reference no. 15. 2. DNA Interaction The physico-chemical characteristics of the anthra cycline-DNA complex, the biological consequences of the anthracycline-DNA interaction as well as free radical damage caused by anthracyclines will be discussed in other chapters of this volume.

V. injections of equally toxic doses. b Observation period, one year. 20 rats per group. Erb~ The agent was shown to intercalate into DNA with an affinity equivalent to that of daunomycin (36). As our studies show, the agent is also a mutagen in a bacterial mutagenesis assay with the strain TA98 of Salmonella typhimurium (Table 8). Table 8. Mutagenic activity of 4-demethoxydaunomycin with strain TA98 of Salmonella t,Hhimurium Compound Concentration (~g/plate) Control Adriamycin 4-Demethoxydaunomycin Relative Survivors(%) His+Revertants/10 6Surv.

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Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981 by F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)


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