By Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)
Androgens and androgen receptors (AR) play serious roles within the improvement and development of prostate melanoma, the main often clinically determined melanoma and moment best reason for melanoma loss of life in US men. AR is an androgen-dependent DNA-binding transcription issue that regulates the expression of androgen-responsive genes. identity and characterization of androgen-responsive genes offer insights into the mobile mechanisms of androgen motion and should result in new techniques in analysis, analysis, prevention and/or therapy of prostate melanoma. This quantity offers severe info from good revered specialists within the box. a number of the fascinating themes comprise the hot knowing of mechanisms underlining the legislation of androgen-responsive gene expression, and capabilities of varied androgen-responsive genes in organic techniques crucial in carcinogenesis together with telephone progress, angiogenesis, and epithelial-to-mesenchyme transition (EMT). different vital facets addressed are the present and strength hospital purposes of information on androgen-responsive gene rules and serve as. This publication is meant for researchers, scientists, college, and complex graduate scholars with an curiosity in androgen motion and prostate cancer.
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Extra info for Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications
Burd CJ, Morey LM, Knudsen KE (2006) Androgen receptor corepressors and prostate cancer. Endocr Relat Cancer 13:979–994 14. Levine M, Manley JL (1989) Transcriptional repression of eukaryotic promoters. Cell 59:405–408 15. Zhang J, Lazar MA (2000) The mechanism of action of thyroid hormones. Annu Rev Physiol 62:439–466 16. Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN (2005) The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
5 Allostery While the cognate ligands of the AR are testosterone and dihydrotestosterone, the DNA elements can also be considered ligands rather than merely AR docking sites near the androgen target genes. There are several lines of evidence that indicate that the DNA sequence indeed can modulate the activity of the binding AR. In this section, we will discuss a possible pathway of allosteric signaling from the DBD to the LBD. 1 Differential Effect of Selective Versus Classical AREs Several features of the AR have been studied by monitoring the effect of point mutations on the functionality of the receptor in reporter assays involving simple AREs.
Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN (2005) The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem 280:6511–6519 17. Jorgensen JS, Nilson JH (2001) AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2.
Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications by Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)