Download PDF by Kevin D. Altria (auth.): Analysis of Pharmaceuticals by Capillary Electrophoresis

By Kevin D. Altria (auth.)

ISBN-10: 3322850110

ISBN-13: 9783322850119

ISBN-10: 3322850137

ISBN-13: 9783322850133

During the 1980's the research of prescribed drugs was once ruled by means of excessive Perfor­ mance Liquid Chromatography (HPLC). different separative recommendations akin to fuel Chromato­ graphy and skinny Layer Chromatography provided possible choices yet their quantitative capabili­ ties and/or solute variety couldn't method that of HPLC. nearly all of prescription drugs are ionic and it'd be moderate to imagine that electrophoresis should be worthy within the research of prescription drugs. besides the fact that, the electrophore­ tic tools to be had within the 1980's have been labour in depth and hired post-separation detection approaches. in the course of the past due 1980's and early 1990's wide examine used to be con­ ducted into the probabilities of accomplishing electrophoretic separations in capillaries. This technique allowed online detection and will be played on totally automatic apparatus. This study resulted in the appearance of contemporary day capillary electrophoresis (CE) tools which supply comparable functionality and automation degrees to that of HPLC. study was once additionally taken with constructing functions for CE and specific consciousness was once paid to functions in the pharmaceutical research quarter. those purposes proved that CE can be utilized to quite a lot of drug kinds together with water insoluble and impartial compounds. the power to accomplish effective chiral separations of substances additionally elevated the recognition of the method. CE with oblique UV detection has turn into validated as an easy and potent substitute to ion-exchange chromatography for the selection of small inorganic or natural ions.

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588 (1991) 335-339. 27. Bechet I, Fillet M, Hubert P, and Crommen J, Determination of benzodiazepines by micellar electrokinetic chromatography, Electrophoresis, 15 (1994) 1316-1321. 28. Sun P, Mariano GJ, Barker G, and Hartwick RA, Comparison of micellar electrokinetic capillary chromatography and high-performance liquid chromatography on the separation and determination of caffeine and its analogues in pharmaceutical tablets, Anal. , 27 (1994) 927-937. 29. Nishi H, Fukayama T, Matsuo M, and Terabe S, Separation and determination of the ingredients of a cold medicine by micellar electrokinetic chromatography with bile salts, 1.

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Analysis of Pharmaceuticals by Capillary Electrophoresis by Kevin D. Altria (auth.)

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