John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr.'s Airway Mucus: Basic Mechanisms and Clinical Perspectives PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

ISBN-10: 3034888740

ISBN-13: 9783034888745

ISBN-10: 3034898096

ISBN-13: 9783034898096

Conceptually unsavoury, airway mucus is essential to homeostasis within the breathing tract. against this, while irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial illnesses, together with bronchial asthma, persistent bronchitis and cystic fibrosis. This quantity presents vast ranging and in-depth assurance of the medical and medical elements of airway mucus. It commences with introductory chapters which deal with the biochemical and molecular organic foundation of airway mucus and maintains with accomplished insurance of some of the physiological and rheological facets of breathing secretions. The scientific elements of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory ailments of the airway. the quantity concludes with a dialogue of the healing points of the subject, either by way of the potential methods to the therapy of mucus hypersecretion and the interplay of those medications with airway mucus. Written by means of major specialists within the box, each one contribution offers a accomplished evaluation of its specific topic. Reflecting the newest advances during this very important region of respiration study, this quantity may be of serious curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Extra info for Airway Mucus: Basic Mechanisms and Clinical Perspectives

Example text

A schematic model of a glycosylated mucin glycoprotein. A MUC protein backbone, encoded by its MUC gene, is generally characterized by tandem repeats of unique sequences containing serine and/or threonine and proline and unique amino and carboxyl termini domains. Hundreds of O-glycans, attached to serine and threonine residues in the MUC backbone, are synthesized in a stepwise manner by specific glycosyltransferases [11]. Some N-glycosylation sites (NXS/T) in MUC protein backbones can be occupied (see text).

For example, one of the four major Table 2. '" r«/////AI I10'/ AI V///U//Z11 V v I . > ,~~'\ I MUCS MUC7' MUC 6 MUC58 MUC5AC MUC 4 MUC3 MUC2' MUC l' Figure 2. Models of MUC primary structures deduced from nucleotide sequences of completed MUC genes (*) or cDNA clones. Specific motifs - TRs, degenerate TRs, TSP-rich domains, cysteine-rich domains transmembrane (TM) and cytoplasmic tail (CT) domains - are depicted. The number of amino acids in MUC-specific TRs is given in Table I. The number ofTRs in a specific MUC or clone is given in the text and/or in references: MUC I [13, 25, 26], MUC2 [24], MUC3 [15], MUC4 [16], MUCS/SAC [17,18,48], MUCS8 [20, 39], MUC6 [21], MUC7 [22] and MUC8 [23, 30].

Indeed, the study by Sheehan et al. [44, 84], in which both radiolabelling and chemical detection methods were used in parallel, shows that both the size and quantity of the "mature" mucins would be underestimated by using radioactivity alone. Thus, the extent to which the results of investigations into mucin biosynthesis and secretion where radiolabels have been used as the sole markers for mucins are applicable to the large oligomeric mucins remains in doubt. The macromolecular assembly of the large oligomeric gel-forming mucins in the respiratory tract is little studied or understood.

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Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)


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