By F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio (auth.), Prof. G. Mathé, Dr. G. Bonadonna, Prof. S. Salmon (eds.)
Transplantation of syngeneic (donor is a monozygous dual) or allogeneic (donor is an HLA-identical sibling) marrow offers the chance for competitive antileukemic treatment with no regard to marrow toxicity. until eventually 1975, marrow transplantation was once performed purely after failure of all different remedy. hence, such a lot sufferers have been in complex relapse. Six of sixteen recipients of syngeneic marrow and thirteen of a hundred recipients of allogeneic marrow are nonetheless in remission after five. 5-10 years [3, 7]. An actuarial survival curve of the 1st a hundred sufferers grafted in Seattle after conditioning with cyclophos phamide (60 mg/kg on each one of two successive days) and overall physique irradiation (1,000 rad) confirmed 3 classes of curiosity: (1) the 1st four months confirmed a fast lack of sufferers linked to complex disorder, graft-versus-host sickness, infections (in specific interstitial pneumonias), and recurrent leukemia; (2) from four months to two years, the curve confirmed a miles slower fee of decline attributable essentially to recurrent leukemia; and (3) from 2-10 years, the curve was once virtually flat with a negligible lack of sufferers and no recurrent leukemia. This flat element of the curve corresponded to thirteen% of the sufferers and exhibits a robust likelihood that most of those survivors are cured in their disorder . makes an attempt at lowering the prevalence of leukemic relapse after transplantation have been made by means of a few marrow transplant teams through extra chemotherapy.
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Extra info for Adjuvant Therapies of Cancer
Lancet 1: 697-699 6. An Intensive Chemo- or Chemoimmunotherapy Regimen for Patients with Intermediate and Poor-Prognosis Acute Lymphatic Leukemia and Leukemic Lymphoblastic Lymphosarcoma: Preliminary Results with 14-Month Median Follow-Up J. L. Misset, F. De Vassal, M. Delgado, P. Ribaud, M. Musset, T. Dorval, D. Machover, C. Jasmin, M. Hayat, L. Schwarzenberg, and G. Mathe Institut de Cancerologie et d'Immunogenetique, (INSERM V-40), H6pital Paul-Brousse, F-94800 Villejuif, France Introduction We previously reported the prognostic factors that can be identified at the onset of acute lymphoid leukemia (ALL) .
Certainly our own experience , while not denying that it is possible to detect metastases earlier through the sequential assay of CEA, would tend to support the view that when rising levels of CEA are detected such patients generally have a significant and widespread tumour load. Breast Carcinoma There are at present no satisfactory indexes to detect, with precision, residual or metastatic breast cancers . CEA, in association with the enzymes a-glutamyltranspeptidase and total alkaline phosphatase, have been shown to be of limited assistance.
Br J Haematol 33: 451-458 Berger R, Bernheim A, BrouetJC, Daniel MT, Flandrin G (1979) (8; 14) Translocation in a Burkitt's type of lymphoblastic leukemia (L:J). Br J Haematol 43: 87 -90 Brouet JC, Preud'homme JL, Seligmann M (1975) The use of Band T membrane markers in the classification of human leukemias with special reference to acute lymphoblastic leukemia. Blood Cells 1: 81-90 Harousseau JL, Tobelem G, Schaison G, Chastang C, Auclerc MF, Weil M, Jacquillat CI, Bernard J (1978) High-risk acute lymphocytic leukemia.
Adjuvant Therapies of Cancer by F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio (auth.), Prof. G. Mathé, Dr. G. Bonadonna, Prof. S. Salmon (eds.)